Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH | CAS 1662688-20-1

Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH (CAS 1662688-20-1) is a protected lipidated lysine building block designed for use in Fmoc-based peptide synthesis and side-chain assembly.

Unlike a simple protected lysine derivative, the molecule already combines an Fmoc-protected lysine framework with AEEA-AEEA, γ-Glu and a protected C18 lipid-derived segment. This preassembled architecture allows the modified lysine unit to be evaluated as a complete building block within an established peptide-synthesis route.

Juntai's current specification sets a purity requirement of ≥97.0%, with control of individual impurities and water content.

Product Information

Structural Characteristics

CAS 1662688-20-1 combines several functional structural elements within one protected amino-acid unit. The molecule can be understood as a preassembled sequence of:

Fmoc-Lys → AEEA-AEEA → γ-Glu → protected C18 lipid-derived segment

Each part contributes a different function to the overall structure.

Fmoc-Protected Lysine Framework

The Fmoc-protected lysine residue provides the amino-acid framework required for incorporation into an Fmoc-based peptide synthesis strategy. The lipidated side-chain architecture is already connected to the lysine residue before the modified amino acid enters the peptide-assembly sequence.

AEEA-AEEA Linker Segment

AEEA-AEEA forms part of the linker region between lysine and the downstream lipidated structure. Its oxygen-containing chain provides a defined spacer within the side-chain architecture.

For further information on this linker unit, see AEEA-AEEA (CAS 1143516-05-5).

γ-Glu and the C18 Lipid-Derived Segment

The γ-Glu unit connects the linker region with the long-chain lipid-derived portion of the molecule. The protected C18 segment represents the long-chain component of the preassembled side chain.

A related upstream long-chain building block is Octadecanedioic Acid Mono-tert-butyl Ester (CAS 843666-40-0).

Role in Fmoc-Based Peptide Synthesis

The defining feature of CAS 1662688-20-1 is the degree of preassembly already present before peptide-chain incorporation. Rather than introducing a basic lysine residue first and constructing the entire side chain through several later operations, the modified lysine already contains the AEEA-AEEA, γ-Glu and protected C18-related structure.

This makes the material particularly relevant to synthesis strategies based on preassembled modified amino-acid building blocks. In such routes, the intermediate is evaluated according to its structural identity, protection pattern, purity and compatibility with the intended peptide-assembly process.

The product should not be treated as equivalent to a separate fatty-acid side-chain fragment. Materials at different stages of side-chain assembly serve different process roles and should be selected according to the established synthesis route.

Quality Specification

Juntai applies an enterprise specification covering identity, purity, individual impurities, water and storage conditions.

The values above represent the product specification rather than the analytical result of a single batch. Batch-specific results are reported separately in the corresponding Certificate of Analysis.

Quality Control and Batch Documentation

For a structurally complex peptide building block, quality evaluation should not rely on a single headline purity value. Confirmation of identity and control of individual impurities are also important when comparing batches or evaluating a material for an established process.

Juntai's specification separately controls purity, maximum single impurity and water content, while identification is included as an independent test item. A batch-specific Certificate of Analysis can be used to review the actual analytical results for supplied material.

This separation between long-term specification and batch-specific results helps procurement, R&D and quality teams evaluate the material against the same defined quality criteria.

Storage and Handling

Store the material protected from light and in a dry environment. The recommended storage temperature is ≤ -18°C.

Because the specified appearance may range from a white to light yellow liquid to a glassy solid, physical form alone should not be used as the sole basis for product identification. Identification and other analytical results should be checked against the applicable batch documentation.

Related Peptide Side-Chain Building Blocks

The following materials belong to related linker and long-chain side-chain building-block systems:

AEEA-AEEA | CAS 1143516-05-5

A linker intermediate used in peptide-related side-chain and conjugation chemistry.

Octadecanedioic Acid Mono-tert-butyl Ester | CAS 843666-40-0

A mono-protected C18 dicarboxylic-acid derivative used as a long-chain building block in related side-chain synthesis.

tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu | CAS 1118767-16-0

A protected long-chain side-chain fragment representing a different stage of side-chain assembly.

Fmoc-L-Lys[C20-OtBu-γ-Glu(OtBu)-AEEA-AEEA]-OH | CAS 2915356-76-0

A related preassembled lipidated lysine building block containing a C20 long-chain segment.

Information for Product Evaluation

When evaluating CAS 1662688-20-1 for a peptide-synthesis project, it is useful to confirm the complete chemical structure, required protection state and target specification before comparing commercial supply options.

For a specific inquiry, the product name or CAS number, required quantity and any project-specific specification requirements can be provided for review.

Frequently Asked Questions

What type of intermediate is CAS 1662688-20-1?

CAS 1662688-20-1 is a protected lipidated lysine building block. It already incorporates Fmoc-Lys, AEEA-AEEA, γ-Glu and a protected C18 lipid-derived segment within one molecule.

What is the purity specification for CAS 1662688-20-1?

Juntai's current specification requires a purity of ≥97.0%. Maximum single impurity is controlled at ≤0.2%, and water at ≤2.0%.

How is CAS 1662688-20-1 different from CAS 1118767-16-0?

CAS 1662688-20-1 already contains the lipidated side-chain architecture attached to Fmoc-Lys. CAS 1118767-16-0 remains a separate protected side-chain fragment and represents a different stage of assembly.

How should CAS 1662688-20-1 be stored?

The material should be protected from light and stored in a dry place. Juntai's current specification recommends a storage temperature of ≤ -18°C.

Is batch-specific analytical documentation available?

The Certificate of Analysis reports the actual analytical results for the applicable batch, while the product page presents the long-term quality specification used for product evaluation.