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Fmoc-L-Lys[Oct-OtBu-γ-Glu(OtBu)-AEEA-AEEA]-OH | CAS 1662688-20-1
- cas：1662688-20-1
- Molecular Formula：
- Purity：99%
- Molecular Weight：
This product is for research and development use only.
Product Details;
CasNo： 1662688-20-1
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH Chemical Properties
|
Boiling point |
1215.5±65.0 °C(Predicted) |
|
density |
1.130±0.06 g/cm3(Predicted) |
|
storage temp. |
-20°C |
|
solubility |
DMSO: Soluble: =10 mg/ml Ethanol: Soluble: =10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml |
|
form |
Liquid (Density: 1.130±0.06 g/cm3) |
|
pka |
3.87±0.21(Predicted) |
|
color |
Colorless to light yellow |
|
InChIKey |
COTQASXXEXJBOM-PJYGOTMFSA-N |
|
SMILES |
C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)N[C@H](C(O)=O)CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](C(OC(C)(C)C)=O)NC(=O)CCCCCCCCCCCCCCCCC(OC(C)(C)C)=O |
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH Usage And Synthesis
|
Description |
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH (CAS 1662688-20-1, purity 99%), also known as the semaglutide side chain, is the core building block of the antidiabetic and weight-loss drug semaglutide. Semaglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist, primarily used for the treatment of type 2 diabetes, chronic weight management and the reduction of the risk of major cardiovascular events. It works by mimicking a natural hormone to suppress appetite, slow digestion and regulate blood glucose levels. |
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Uses |
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH is a useful compound in the chemical research. |
|
Definition |
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH is a useful research chemical used in the preparation of semaglutide. Reagent grade, for research purpose. |
|
References |
[1] IVAN GURYANOV*. Copper(II) Lysinate and Pseudoproline Assistance in the Convergent Synthesis of the GLP-1 Receptor Agonists Liraglutide and Semaglutide[J]. Organic Process Research & Development, 2021, 25 7: 1598-1611. DOI: 10.1021/acs.oprd.1c00021 |
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