Fmoc-Glu(OtBu)-Gly-Gly-OH | CAS N/A

Product Details

CasNo： N/A

Molecular Formula： C28H33N3O8

Appearance： White to off-white solid

Delivery Time： Confirmed according to order quantity, target specification, and current supply availability

Packing： 1 g, 5 g, 10 g, 25 g, 100 g or customized packaging

Throughput： Gram to kilogram scale, custom scale-up available

Purity： ≥99%

Fmoc-Glu(OtBu)-Gly-Gly-OH

Fmoc-Glu(OtBu)-Gly-Gly-OH is an Fmoc-protected tripeptide building block containing the protected Glu-Gly-Gly sequence. The N-terminal amino group is protected with Fmoc, while the glutamic acid side-chain carboxyl group is protected as an OtBu ester, leaving the C-terminal carboxyl group available for subsequent peptide coupling.

As a preassembled protected peptide fragment, it can be evaluated in peptide synthesis routes where incorporation of the Glu-Gly-Gly motif is required. Compared with introducing the three amino acid residues individually, a protected tripeptide fragment may provide an alternative route for reducing repetitive coupling operations during process development.

Shandong Juntai Pharmaceutical supplies Fmoc-protected peptide building blocks, protected peptide fragments, and custom peptide intermediates for R&D, route development, and scale-up projects.

Basic Information

Item	Specification
Product Name	Fmoc-Glu(OtBu)-Gly-Gly-OH
Product Type	Fmoc-Protected Tripeptide / Protected Peptide Building Block
Peptide Sequence	Glu-Gly-Gly
N-Terminal Protection	Fmoc
Side-Chain Protection	Glu(OtBu)
Molecular Formula	C28H33N3O8
Molecular Weight	539.23 g/mol
CAS No.	N/A
Purity	≥99%
Appearance	White to off-white solid
Application	Peptide synthesis, fragment coupling, and process development
Packaging	Customized according to order requirements
Delivery Time	Confirmed according to order quantity, target specification, and current supply availability

Product Features

Protected Glu-Gly-Gly Fragment for Peptide Synthesis

Fmoc-Glu(OtBu)-Gly-Gly-OH provides the Glu-Gly-Gly sequence in a preassembled protected form. This makes it suitable for peptide chemists evaluating fragment-based synthesis or alternative coupling strategies during route development.

For projects requiring repeated production of the same peptide sequence, using a protected tripeptide fragment may also help simplify material preparation and reduce the number of individual building blocks involved in selected synthesis stages.

Fmoc and OtBu Protection Strategy

The molecule combines two commonly used protecting groups in peptide chemistry.

The Fmoc group protects the N-terminal amino functionality and is compatible with standard Fmoc-based synthesis workflows. The OtBu group protects the glutamic acid side-chain carboxyl functionality during subsequent coupling operations.

This protection pattern allows the fragment to be incorporated into more complex protected peptide intermediates while maintaining control over reactive functional groups during synthesis.

Suitable for Fragment-Based Route Development

Fmoc-Glu(OtBu)-Gly-Gly-OH can be considered when developing synthetic routes involving protected peptide fragments rather than exclusively using residue-by-residue assembly.

Its value is especially relevant during:

• Fragment coupling evaluation
• Peptide route screening
• Intermediate preparation
• Process optimization
• Scale-up feasibility studies
• Custom peptide intermediate development

Research and Process Applications

Fmoc-Based Peptide Synthesis

The product can be used as an Fmoc-protected peptide synthesis intermediate in routes requiring a protected Glu-Gly-Gly segment.

The free C-terminal carboxyl group allows further activation and coupling according to the selected synthesis strategy.

Protected Peptide Fragment Coupling

For fragment-based peptide assembly, Fmoc-Glu(OtBu)-Gly-Gly-OH can serve as a protected tripeptide unit for coupling with amino acids, peptide fragments, or other protected intermediates.

This makes it relevant for researchers and process-development teams searching for a protected Glu-Gly-Gly peptide fragment supplier rather than preparing the fragment internally from individual amino acids.

Peptide Process Development

During peptide process development, preassembled fragments may be evaluated as an alternative to sequential amino acid incorporation.

Whether a fragment-based route is preferable depends on factors such as target peptide sequence, coupling efficiency, impurity profile, purification strategy, and required production scale.

For this reason, Fmoc-Glu(OtBu)-Gly-Gly-OH is more appropriately positioned as a process-development building block rather than as a universal replacement for conventional solid-phase peptide synthesis.

Custom Synthesis Support

Shandong Juntai Pharmaceutical supports customers requiring protected peptide intermediates and customized peptide building blocks beyond standard catalogue products.

For projects involving Fmoc-Glu(OtBu)-Gly-Gly-OH or structurally related peptide fragments, technical discussions can cover target purity, batch quantity, analytical requirements, downstream route compatibility, and scale-up requirements.

Custom support may include protected amino acids, short peptide fragments, sequence-specific intermediates, and non-standard protected peptide building blocks.

For sourcing teams looking for a Fmoc peptide intermediate supplier in China, project information can be reviewed before quotation so that specification and supply arrangements match the intended development stage.

FAQ

What information should I provide when requesting a quotation for Fmoc-Glu(OtBu)-Gly-Gly-OH?

Please provide the required quantity, target purity or specification, destination country, packaging preference, and any special analytical requirements. For development projects, expected scale and purchasing frequency are also helpful for quotation and supply planning.

Can I request a small evaluation quantity before placing a larger order?

Evaluation quantities can be discussed according to current material availability and project requirements. This is suitable for customers testing a protected tripeptide building block before moving to larger-volume procurement.

What analytical documents can be provided with the material?

Batch documentation can include a Certificate of Analysis and relevant analytical results according to the agreed specification. If HPLC, MS, moisture, residual solvent, or other specific testing is required, these items should be confirmed before order placement.

Can Fmoc-Glu(OtBu)-Gly-Gly-OH be supplied for scale-up or repeat orders?

Yes, scale-up and repeat supply can be evaluated according to required quantity, target specification, analytical requirements, and current supply conditions. Customers planning larger or recurring orders are encouraged to provide projected demand in advance.

Can you provide related protected peptide fragments or custom peptide intermediates?

Yes. Juntai can evaluate custom synthesis requests for Fmoc-protected peptide fragments, protected amino acid derivatives, and sequence-specific peptide intermediates. Please provide the target structure or sequence, protecting-group requirements, quantity, and expected purity for project assessment.

This product is for research and development use only.