5988-19-2
- Product Name：L-4,5-dihydroorotic acid
- Molecular Formula：C5H6N2O4
- Purity：99%
- Molecular Weight：158.114
Product Details;
CasNo： 5988-19-2
Molecular Formula： C5H6N2O4
Appearance： White to off-white crystalline powder
Quality Factory Sells Top Purity 99% L-4,5-dihydroorotic acid 5988-19-2 with Safe Delivery
- Molecular Formula:C5H6N2O4
- Molecular Weight:158.114
- Appearance/Colour:White to off-white crystalline powder
- Melting Point:254-255 °C (dec.)(lit.)
- Refractive Index:1.519
- Boiling Point:283.16°C (rough estimate)
- PKA:2.82±0.20(Predicted)
- PSA：95.50000
- Density:1.524 g/cm3
- LogP:-0.67330
L-DIHYDROOROTIC ACID(Cas 5988-19-2) Usage
|
Biochem/physiol Actions |
L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors. |
InChI:InChI=1/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1
5988-19-2 Process route
-
-
5988-19-2,6202-10-4
L-dihydroorotic acid
| Conditions | Yield |
|---|---|
|
With
sodium ethanolate;
|
-
-
65-86-1,58915-47-2,6784-70-9
orotic acid
-
-
5988-19-2,6202-10-4
L-dihydroorotic acid
| Conditions | Yield |
|---|---|
|
durch enzymatische Reduktion;
|
5988-19-2 Upstream products
-
65-86-1
orotic acid
5988-19-2 Downstream products
-
103300-84-1
benzyl (S)-dihydroorotate
-
65-86-1
orotic acid
-
124798-99-8
(S)-1-Benzyl-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid
-
103300-85-2
benzyl (S)-3-methyldihydroorotate
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