324017-21-2
- Product Name:Fmoc-D-Phe(4-NH2)-OH
- Molecular Formula:C24H22N2O4
- Purity:99%
- Molecular Weight:402.44200
Product Details;
CasNo: 324017-21-2
Molecular Formula: C24H22N2O4
Purity 99% Min Fmoc-D-Phe(4-NH2)-OH 324017-21-2 Spot Supply with Safe Transportation
- Molecular Formula:C24H22N2O4
- Molecular Weight:402.44200
- Boiling Point:671.5±55.0 °C(Predicted)
- PKA:3.63±0.10(Predicted)
- PSA:101.65000
- Density:1.316±0.06 g/cm3(Predicted)
- LogP:4.77530
324017-21-2 Relevant articles
Synthesis of new tetrazolyl derivatives of L- and D-phenylalanine
Tolstyakov,Tolstobrova,Zarubina,Popova,Protas,Chuprun,Trifonov
, p. 1681 - 1685 (2017/01/28)
New tetrazolyl derivatives of L- and D-p...
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites
Geurink, Paul P.,Van Der Linden, Wouter A.,Mirabella, Anne C.,Gallastegui, Nerea,De Bruin, Gerjan,Blom, Annet E. M.,Voges, Mathias J.,Mock, Elliot D.,Florea, Bogdan I.,Van Der Marel, Gijs A.,Driessen, Christoph,Van Der Stelt, Mario,Groll, Michael,Overkleeft, Herman S.,Kisselev, Alexei F.
supporting information, p. 1262 - 1275 (2013/03/29)
Proteasomes degrade the majority of prot...
N-alkanoylphenylalanine derivatives
-
, (2008/06/13)
Compounds of the formula: are disclosed ...
N-aroylphenylalanine derivative VCAM-1 inhibitors
-
, (2008/06/13)
Compounds of the formula: are disclosed ...
324017-21-2 Process route
-
-
95753-55-2,177966-63-1
N-α-FMOC-4-nitro-L-phenylalanine
-
-
95753-56-3,324017-21-2
4-amino-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
for 1h;
|
93% |
|
With
hydrogen;
palladium on activated charcoal;
In
1,4-dioxane;
for 1h;
Ambient temperature;
|
90% |
|
With
hydrogen;
palladium on activated charcoal;
In
methanol;
under 760 Torr;
|
|
|
With
palladium 10% on activated carbon; ammonium formate;
In
methanol;
at 20 ℃;
for 14h;
|
|
|
Multi-step reaction with 2 steps
1: hydrogenchloride; zinc / water; isopropyl alcohol
2: hydrogenchloride; water / 6 h / Reflux
With
hydrogenchloride; water; zinc;
In
water; isopropyl alcohol;
|
-
-
95753-55-2,177966-63-1
N-α-FMOC-4-nitro-L-phenylalanine
-
-
isopropyl ether of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-amino-L-phenylalanine
-
-
95753-56-3,324017-21-2
4-amino-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; zinc;
In
water; isopropyl alcohol;
|
324017-21-2 Upstream products
-
95753-55-2
N-α-FMOC-4-nitro-L-phenylalanine
-
943-80-6
4-amino-L-phenylalanine
-
82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
-
949-99-5
4-nitro-3-phenyl-L-alanine
324017-21-2 Downstream products
-
95753-57-4
N-Fmoc-L-p-aminophenylalanine methyl ester hydrochloride
-
214750-77-3
N-α-(9-fluoromethoxycarbonyl)-L-4-tert-butoxycarbonylaminophenylalanine
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-
CDI
CAS:530-62-1
-
Elexacaftor
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