Elexacaftor
  • Elexacaftor

Elexacaftor | CAS 2216712-66-0

  • cas:2216712-66-0
  • Molecular Formula:
  • Purity:99%
  • Molecular Weight:597.662
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Product Details;

CasNo: 2216712-66-0

Cost-effective customized wholesale Elexacaftor 2216712-66-0

  • Molecular Formula:C26H34F3N7O4S
  • Molecular Weight:597.662
  • Melting Point:206 - 208°C 
  • Density:1.38±0.1 g/cm3(Predicted) 

2216712-66-0Relevant academic research and scientific papers

PROCESSES FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

-

Paragraph 0637; 0640; 0645-0646, (2021/08/13)

The disclosure provides processes for preparing a compound of Formula (I).

METHODS OF TREATMENT FOR CYSTIC FIBROSIS

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, (2020/12/11)

This application describes methods of treating cystic fibrosis comprising administering Compound I:, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising any of the foregoing.

METHODS OF TREATMENT FOR CYSTIC FIBROSIS

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, (2019/02/06)

Compound I of the formula (I) and/or pharmaceutically acceptable salt(s) of Compound I comprised in a pharmaceutical composition and methods of using the same to treat cystic fibrosis.

PHARMACEUTICAL COMPOSITIONS FOR TREATING CYSTIC FIBROSIS

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, (2019/08/20)

A pharmaceutical composition comprising Compound I: Methods of treating cystic fibrosis comprising administering one or more of such pharmaceutical compositions to a patient.

MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR

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, (2018/06/30)

Compounds of Formula (I) pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

2216712-66-0 Process route

(4S)-2,2,4-trimethylpyrrolidine hydrochloride salt

(4S)-2,2,4-trimethylpyrrolidine hydrochloride salt

2-chloro-N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethyl-propoxy)pyrazol-1-yl]pyridine-3-carboxamide

2-chloro-N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethyl-propoxy)pyrazol-1-yl]pyridine-3-carboxamide

N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide
2216712-66-0

N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide

Conditions
Conditions Yield
With potassium carbonate; In monoethylene glycol diethyl ether; at 120 ℃; for 16h; Solvent; Temperature; Large scale;
90%
With potassium carbonate; In monoethylene glycol diethyl ether; dimethyl sulfoxide; at 120 ℃; Temperature; Solvent;
90%
With potassium carbonate; In monoethylene glycol diethyl ether; dimethyl sulfoxide; at 120 ℃; for 16h; Solvent; Temperature;
90%
With potassium carbonate; In monoethylene glycol diethyl ether; dimethyl sulfoxide; at 120 ℃; Temperature; Solvent;
90%
With potassium carbonate; In 1,2-dimethoxyethane; dimethyl sulfoxide; at 120 ℃; for 16h; Solvent; Temperature;
90%
(4R)-2,2,4-trimethylpyrrolidine hydrochloride salt

(4R)-2,2,4-trimethylpyrrolidine hydrochloride salt

2-chloro-N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethyl-propoxy)pyrazol-1-yl]pyridine-3-carboxamide

2-chloro-N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethyl-propoxy)pyrazol-1-yl]pyridine-3-carboxamide

N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4R)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide
2216712-66-0

N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4R)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide

Conditions
Conditions Yield
With potassium carbonate; In 1-methyl-pyrrolidin-2-one; monoethylene glycol diethyl ether; at 130 ℃; for 40h;
61%

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