Fmoc-Lys(iPr,Boc)-OH | CAS 201003-48-7

Product Details

CasNo： 201003-48-7

Molecular Formula： C29H38N2O6

Appearance： White to light yellow or beige powder

Delivery Time： Confirmed according to order quantity, target specification, and current supply availability.

Packing： 1 g / 5 g / 10 g / 25 g / customized packaging available

Throughput： Custom synthesis and scale-up available

Purity： ≥97%

Fmoc-Lys(iPr,Boc)-OH | CAS 201003-48-7

Fmoc-Lys(iPr,Boc)-OH is a protected lysine derivative and specialized peptide synthesis building block used in Fmoc-based solid-phase peptide synthesis (SPPS).

Unlike standard Fmoc-Lys(Boc)-OH, this derivative contains an isopropyl substituent on the ε-nitrogen of lysine. Its main function is therefore not simply to introduce a lysine residue, but to enable the incorporation of Nε-isopropyl-L-lysine [Lys(iPr)] at a defined position in a peptide sequence.

This makes Fmoc-Lys(iPr,Boc)-OH relevant for modified peptide synthesis, sequence-specific peptide development, and process routes requiring controlled introduction of Lys(iPr) residues. Public peptide-synthesis references also document the use of Lys(iPr)-containing building blocks in peptides such as Degarelix and Antide.

Basic Information

Item	Specification
Product Name	Fmoc-Lys(iPr,Boc)-OH
Alternative Name	N-α-Fmoc-N-ε-isopropyl-N-ε-Boc-L-lysine
CAS No.	201003-48-7
Molecular Formula	C29H38N2O6
Molecular Weight	510.62 g/mol
Product Type	Fmoc-Protected Lysine Derivative / Peptide Building Block
Key Modification	Nε-Isopropyl-L-lysine precursor
Purity	≥97%
Appearance	White to light yellow or beige powder
Application	Fmoc-SPPS and modified peptide synthesis
Storage	2–8°C
Packaging	Customized packaging available
Delivery Time	Confirmed according to order quantity, target specification, and current supply availability

The molecular formula, molecular weight, product form, Fmoc-SPPS suitability, and storage information are consistent with current Novabiochem product data. 

Product Features

Specialized Lys(iPr) Building Block

Fmoc-Lys(iPr,Boc)-OH is designed for the introduction of Nε-isopropyl-L-lysine residues during peptide synthesis.

The α-amino group is protected by Fmoc, allowing compatibility with conventional Fmoc-SPPS cycles, while the modified ε-amino functionality carries both the isopropyl substituent and Boc protection required for controlled peptide assembly.

This structural design makes the product particularly useful when a target peptide requires site-specific lysine side-chain modification rather than incorporation of an unmodified lysine residue.

Compatible with Fmoc Solid-Phase Peptide Synthesis

The product is suitable for use in standard Fmoc-based solid-phase peptide synthesis workflows.

During peptide assembly, the carboxyl group participates in peptide-bond formation, while the Fmoc-protected α-amino group allows controlled deprotection and continuation of peptide chain elongation.

Sigma/Novabiochem specifically identifies the product for Fmoc solid-phase peptide synthesis and peptide synthesis applications. 

Distinct from Fmoc-Lys(Boc)-OH

Fmoc-Lys(iPr,Boc)-OH should not be confused with conventional Fmoc-Lys(Boc)-OH.

The two building blocks have different side-chain structures and therefore introduce different residues into the final peptide:

Building Block	Residue Introduced
Fmoc-Lys(Boc)-OH	L-Lysine
Fmoc-Lys(iPr,Boc)-OH	Nε-Isopropyl-L-lysine [Lys(iPr)]

This distinction is important when sourcing building blocks for modified peptide sequences, because substituting one for the other changes the chemical structure of the final peptide. PubChem lists Fmoc-Lys(Boc)-OH separately with formula C26H32N2O6 and MW 468.5, confirming that it is a distinct compound. 

Suitable for Sequence-Specific Modified Peptides

Because Lys(iPr) is a defined side-chain modification, Fmoc-Lys(iPr,Boc)-OH is useful in peptide projects where modification at a specific lysine position is part of the target structure.

This includes research, route development, and process optimization for peptides containing modified lysine residues.

Research and Process Applications

Fmoc-SPPS of Lys(iPr)-Containing Peptides

Fmoc-Lys(iPr,Boc)-OH can be introduced at the required position in a growing peptide chain using an appropriate Fmoc-SPPS coupling strategy.

After successful incorporation, the synthesis proceeds through subsequent Fmoc deprotection and amino-acid coupling cycles according to the target peptide sequence.

Its key role is the controlled introduction of Nε-isopropyl-L-lysine, rather than general lysine protection.

Modified Peptide Development

The product can be used in projects involving:

• Modified peptide sequence development
• Lysine side-chain engineering
• Peptide structure–activity research
• Peptide route optimization
• Process development for non-standard amino acid incorporation

This makes it relevant for peptide R&D teams evaluating chemically modified residues within defined peptide sequences.

Degarelix and Antide-Related Peptide Chemistry

Public Novabiochem documentation notes that Lys(iPr) has been used in the GnRH antagonist Degarelix and the LHRH antagonist Antide. 

For this reason, Fmoc-Lys(iPr,Boc)-OH is relevant to synthetic strategies involving peptides that require Lys(iPr) residues.

However, the product should be positioned as a general Lys(iPr) peptide building block, rather than being described exclusively as a Degarelix intermediate.

Peptide Route and Process Development

For scale-up or route-development projects, modified amino acid building blocks must be evaluated not only for identity and purity but also for their behavior during coupling, deprotection, impurity formation, and downstream purification.

Fmoc-Lys(iPr,Boc)-OH can therefore be considered during development of robust synthetic routes for peptides containing Nε-isopropyl-lysine.

Custom Synthesis Support

Shandong Juntai Pharmaceutical supports the supply and custom development of Fmoc-protected amino acids, modified lysine derivatives, protected peptide building blocks, and peptide intermediates for R&D and process-development projects.

Custom requirements can be evaluated according to:

• Target structure
• Purity specification
• Impurity requirements
• Analytical methods
• Batch quantity
• Scale-up requirements
• Repeat supply demand
• Customized packaging

For customers sourcing a Fmoc-Lys(iPr,Boc)-OH supplier, modified lysine building blocks, or other Fmoc amino acid derivatives, project specifications can be discussed before quotation to ensure that material requirements match the intended synthesis route.

FAQ

What information should I provide when requesting a quotation for Fmoc-Lys(iPr,Boc)-OH?

Please provide the required quantity, target purity or specification, destination, packaging preference, and any special analytical requirements. For repeat or scale-up projects, projected demand is also helpful for supply planning.

Can I request an evaluation quantity before placing a larger order?

Evaluation quantities can be discussed according to current material availability and project requirements. This is useful for peptide R&D teams evaluating a Lys(iPr) building block in a new synthesis route before larger-scale procurement.

What analytical documentation can be provided with each batch?

Available documentation can include a Certificate of Analysis and relevant analytical results according to the agreed specification. Requirements for HPLC, MS, optical purity, moisture, residual solvents, or other testing items should be confirmed before order placement.

Can purity or impurity specifications be customized?

Project-specific specifications can be evaluated according to technical feasibility. Customers working on peptide process development may discuss target purity, impurity limits, analytical methods, and other control requirements before quotation.

Can Juntai supply related modified lysine derivatives or Fmoc peptide building blocks?

Yes. Juntai can evaluate custom synthesis requirements for modified lysine derivatives, Fmoc-protected amino acids, protected peptide building blocks, and sequence-specific peptide intermediates. Providing the target structure, required quantity, purity, and analytical requirements will help accelerate project assessment.

For research, process development, and industrial applications only. Product specifications and supply arrangements should be confirmed according to individual project requirements.