What is the 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid?

18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid is , while it's Molecular Formula is C 39 H 66 N 4 O 15 . Used in Pharmaceutical Industry: Lomitapide is used as a lipid-lowering agent for the treatment of patients with homozygous familial hypercholesterolemia (HoFH). It is used as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, to reduce low-density lipoprotein cholesterol levels. The reason for its use is its ability to inhibit the synthesis of apolipoprotein B in the liver, which is essential for the formation and secretion of VLDL and IDL, the precursors of LDL. This action helps lower plasma LDL-cholesterol levels in HoFH patients, who have a genetic disorder that leads to extremely high levels of LDL cholesterol in the blood.

What is the CAS number for 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid?

The CAS number of 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid is 1169630-40-3.

What is 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid (1169630-40-3) used for?

18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid, also known as Lomitapide, is a novel inhibitor of microsomal triglyceride transfer protein (MTP). It is an orally active agent that inhibits the synthesis of apolipoprotein B in the liver, which is required for the formation and secretion of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL), the precursors of low-density lipoprotein (LDL). Lomitapide is used as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, to reduce LDL cholesterol in patients with homozygous familial hypercholesterolemia (HoFH). It has a unique structure and mechanism of action as a selective MTP inhibitor.

What is the 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid?

18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid is , while it's Molecular Formula is C 39 H 66 N 4 O 15 . Used in Pharmaceutical Industry: Lomitapide is used as a lipid-lowering agent for the treatment of patients with homozygous familial hypercholesterolemia (HoFH). It is used as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, to reduce low-density lipoprotein cholesterol levels. The reason for its use is its ability to inhibit the synthesis of apolipoprotein B in the liver, which is essential for the formation and secretion of VLDL and IDL, the precursors of LDL. This action helps lower plasma LDL-cholesterol levels in HoFH patients, who have a genetic disorder that leads to extremely high levels of LDL cholesterol in the blood.

What is the CAS number for 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid?

The CAS number of 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid is 1169630-40-3.

What is 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid (1169630-40-3) used for?

18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid, also known as Lomitapide, is a novel inhibitor of microsomal triglyceride transfer protein (MTP). It is an orally active agent that inhibits the synthesis of apolipoprotein B in the liver, which is required for the formation and secretion of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL), the precursors of low-density lipoprotein (LDL). Lomitapide is used as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, to reduce LDL cholesterol in patients with homozygous familial hypercholesterolemia (HoFH). It has a unique structure and mechanism of action as a selective MTP inhibitor.

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1169630-40-3

Product Name：Ste-γ-Glu-AEEA-AEEA-Osu
Molecular Formula：
Purity：99%
Molecular Weight：830.971

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Product Details;

CasNo： 1169630-40-3

Chinese Factory Supply Wholesale Ste-γ-Glu-AEEA-AEEA-Osu 1169630-40-3 with Cheap Price

Molecular Formula:C₃₉H₆₆N₄O₁₅
Molecular Weight:830.971

1169630-40-3 Relevant articles

Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320

Kjeldsen, Thomas B.,Hubálek, Franti?ek,Tagmose, Tina M.,Pridal, Lone,Refsgaard, Hanne H. F.,Porsgaard, Trine,Gram-Nielsen, Sanne,Hovgaard, Lars,Valore, Henrik,Münzel, Martin,Hj?rringgaard, Claudia U.,Jeppesen, Claus Bekker,Manfè, Valentina,Hoeg-Jensen, Thomas,Ludvigsen, Svend,Nielsen, Peter Kresten,Lautrup-Larsen, Inger,Stidsen, Carsten E.,Wulff, Erik M.,Garibay, Patrick W.,Kodra, János T.,Nishimura, Erica,Madsen, Peter

, p. 616 - 628 (2021)

Recently, the first basal oral insulin (...

Novel GLP-1 Analogues

-

, (2019/10/20)

The present disclosure pertains to novel...

1169630-40-3 Process route

: 843666-40-0
1,18-octadecanedioic acid mono-tert-butyl ester

: 1169630-40-3
18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine 2: isobutyl chloroformate; 4-methyl-morpholine 3: trifluoroacetic acid With 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate;
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h 1.2: 0.17 h 2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C 3.1: trifluoroacetic acid / 1 h / 20 °C With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
Multi-step reaction with 6 steps 1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C 2: water; N,N-dimethyl-formamide / 20 °C 3: tetrahydrofuran; acetonitrile / 20 °C 4: N-ethyl-N,N-diisopropylamine / ethanol / 20 °C 5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C 6: trifluoroacetic acid / 1 h / 20 °C With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

: 1169630-40-3
18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-4-oxobutyl]amino]-18-oxooctadecanoic acid

: 4-aminomethyl-benzaldehyde

: 18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-[(4-formylphenyl)methylamino]-2-oxo-ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]ethoxy]ethylamino]-4-oxo-butyl]amino]-18-oxo-octadecanoic acid

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 2.16667h;	234 mg

1169630-40-3 Upstream products

843666-40-0
1,18-octadecanedioic acid mono-tert-butyl ester

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