Retatrutide | CAS 2381089-83-2

Product Details

CasNo： 2381089-83-2

Molecular Formula： C221H342N46O68

Appearance： White to off-white lyophilized powder

Delivery Time： Confirmed according to order quantity, target specification, analytical requirements, and current supply availability

Packing： Available according to order quantity and project requirements

Throughput： Evaluated based on project requirements, specifications, and order quantity

Purity： ≥99.0% by HPLC

Product Overview

Retatrutide, CAS 2381089-83-2, also known by the development code LY3437943, is a 39-amino-acid synthetic lipidated peptide designed for research involving GIP, GLP-1, and glucagon receptor signaling.

Retatrutide contains non-natural amino acid residues, a lipidated lysine side chain, and a C-terminal amide. These structural features distinguish it from conventional linear peptides and make product identity, modification integrity, impurity control, peptide content, and residual solvent analysis important parts of quality evaluation.

Shandong Juntai Pharmaceutical supports B2B supply of Retatrutide for peptide R&D, receptor pharmacology research, analytical development, and related laboratory projects. A current production batch has been evaluated for HPLC purity, individual impurities, water content, peptide content, residual solvents, microbial limits, and bacterial endotoxin.

Retatrutide remains an investigational molecule and should be positioned for research and development use rather than as a marketed therapeutic product.

Product Information

Item	Information
Product Name	Retatrutide
Development Code	LY3437943 / LY-3437943
CAS No.	2381089-83-2
Molecular Formula	C221H342N46O68
Molecular Weight	4731.33 g/mol
Peptide Length	39 amino acids
Product Type	Lipidated Synthetic Peptide
Research Category	GIP / GLP-1 / Glucagon Triple Receptor Agonist Peptide
Category	GLP-1 & Metabolic Peptides
Appearance	White to off-white lyophilized powder
HPLC Purity Specification	≥99.0%
Storage	Sealed at -20°C ±5°C
Main Use	Receptor pharmacology research, peptide characterization, analytical method development, and related R&D projects

Product Features

39-Amino-Acid Lipidated Peptide

Retatrutide is a structurally modified 39-residue peptide rather than a simple native peptide sequence.

Its design includes non-natural amino acid residues and a lipidated lysine side chain. These structural elements increase the importance of confirming not only peptide identity and purity, but also modification integrity and related impurities.

For technical evaluation, relevant parameters may include:

• Peptide identity
• Molecular weight
• Sequence and modification integrity
• HPLC purity
• Individual impurities
• Peptide content
• Residual solvents
• Water content
• Batch consistency

Triple Receptor Research Profile

Retatrutide is designed as a GIP / GLP-1 / glucagon triple receptor agonist peptide.

For B2B research applications, the product is therefore more appropriately positioned around:

• Receptor pharmacology research
• Multi-receptor peptide studies
• Metabolic peptide research
• Structure–activity relationship studies
• Lipidated peptide characterization

rather than consumer-facing benefit claims.

More Complex Quality Control Than Conventional Short Peptides

Lipidation and non-natural amino acid incorporation make Retatrutide more analytically complex than a conventional short linear peptide.

A complete quality assessment should therefore consider more than HPLC purity alone. Parameters such as individual impurity, peptide content, water, residual solvents, microbial limits, and bacterial endotoxin can provide a more complete view of batch quality.

Lyophilized Product Form

The current product form is white to off-white lyophilized powder.

For lyophilized peptides, storage temperature, moisture control, packaging integrity, and transport conditions are important to product stability and should follow the applicable batch documentation.

Research Applications

GIP / GLP-1 / Glucagon Receptor Research

Retatrutide may be used in laboratory studies involving GIP, GLP-1, and glucagon receptor signaling and related receptor pharmacology.

Any biological findings should be interpreted within the specific experimental model and should not be presented as established clinical outcomes.

GLP-1 and Metabolic Peptide Research

Retatrutide can be evaluated in projects involving:

• GLP-1-related peptide research
• Multi-receptor agonist design
• Metabolic peptide research
• Lipidated peptide development
• Structure–activity relationship studies
• Peptide modification research

Peptide Characterization

Its modified structure makes Retatrutide suitable for analytical work involving:

• HPLC purity analysis
• MS / LC-MS identity confirmation
• Related impurity analysis
• Peptide content evaluation
• Modification integrity studies
• Batch-to-batch analytical comparison

Analytical Method Development

Retatrutide can also be used in the development and optimization of analytical methods for modified peptides, including:

• HPLC method development
• LC-MS characterization
• Identity testing
• Impurity profiling
• Residual solvent analysis
• Water determination
• Peptide content testing

Quality & Supply

A current Shandong Juntai Pharmaceutical batch has been tested against an established internal quality specification.Representative Batch Quality Data

Test Item	Specification	Representative Batch Result
Appearance	White to off-white lyophilized powder	Complies
Identification	Conforms to reference standard	Complies
pH	6.0–9.0	7.6
Water	≤8.0%	6.3%
Individual Impurity	≤0.5%	0.3%
HPLC Purity	≥99.0%	99.4%
Peptide Content	≥80.0%	92.9%
Methylene Chloride	≤600 ppm	N.D.
Acetonitrile	≤410 ppm	300 ppm
Methanol	≤300 ppm	300 ppm
N,N-Dimethylformamide	≤880 ppm	N.D.
Isopropyl Ether	≤5000 ppm	N.D.
Aerobic Bacterial Count	≤1000 CFU/g	Complies
Mould & Yeast	≤100 CFU/g	Complies
Bacterial Endotoxin	<10 EU/mg	Complies

These values represent a specific tested batch and should not be interpreted as fixed results for every future batch. Final released material should always be evaluated against its corresponding COA.

Key Quality Parameters

For Retatrutide sourcing, buyers may consider:

• HPLC purity
• Individual impurity
• Peptide content
• Identity
• Water content
• Residual solvents
• Microbial limits
• Bacterial endotoxin
• Storage conditions
• Batch-specific COA

Shandong Juntai Pharmaceutical can review supply requirements according to target quantity, purity, packaging, and analytical expectations.

Custom Support

Projects involving Retatrutide and other GLP-1 / metabolic peptides can be evaluated according to the target structure and technical requirements.

Project discussions may include:

• Retatrutide R&D supply
• GLP-1 and metabolic peptide projects
• Lipidated peptide synthesis
• Non-natural amino acid-containing peptides
• Linker and fatty-acid side-chain modification
• Target purity requirements
• HPLC / MS analytical requirements
• Related impurity control
• Project-specific packaging and quantities
• Related peptide analogs

Feasibility is reviewed according to sequence complexity, modification pattern, required quantity, purity target, and analytical requirements.

Frequently Asked Questions

What type of peptide is Retatrutide?

Retatrutide is a 39-amino-acid lipidated synthetic peptide designed for research involving GIP, GLP-1, and glucagon receptor signaling.

Its non-natural amino acids and lipidated side chain make analytical characterization more complex than for a conventional linear short peptide.

What is the CAS number and development code for Retatrutide?

The CAS number is 2381089-83-2.

The commonly used development code is LY3437943 / LY-3437943.

What purity specification is available?

The current product specification is:

HPLC Purity ≥99.0%

A representative tested batch showed 99.4% HPLC purity. Actual release results should always be confirmed against the corresponding batch COA.

Why are HPLC purity and peptide content different?

They measure different aspects of the sample.

HPLC purity mainly reflects the relative proportion of the target peak compared with chromatographically detected impurities.

Peptide content reflects the amount of target peptide present in the overall sample and may be influenced by water, counter-ions, residual materials, and other non-peptide components.

The two values should therefore not be interpreted as equivalent.

Can COA and analytical data be provided?

Retatrutide has batch-specific COA data available.

The exact documentation package provided for a project depends on the released batch and agreed requirements. Additional analytical needs such as MS / LC-MS, impurity evaluation, or residual solvent data can be discussed during the inquiry stage.

How should Retatrutide be stored?

The current batch specification indicates:

Sealed, stored at -20°C ±5°C.

Transport and long-term storage conditions should follow the documentation for the specific batch supplied.

What is the MOQ and packaging format?

MOQ and packaging depend on target specification, purchase quantity, and project requirements.

Special analytical, packaging, or custom project needs can be reviewed before quotation.

Is Retatrutide an approved commercial drug?

Retatrutide remains an investigational molecule and is not positioned here as an approved commercial therapeutic product.

This product is supplied for research, analytical, and development purposes only.

For research and development use only.