536721-25-2
- Product Name：Pal-Glu(OH)-OtBu
- Molecular Formula：C25H47NO5
- Purity：99%
- Molecular Weight：441.652
Product Details;
CasNo： 536721-25-2
Molecular Formula： C25H47NO5
Pal-Glu(OH)-OtBu Good Supplier In Bulk Supply High Purity 536721-25-2
- Molecular Formula:C25H47NO5
- Molecular Weight:441.652
- Melting Point:62-65°C
- Boiling Point:591.0±40.0 °C(Predicted)
- PKA:4.44±0.10(Predicted)
- PSA：99.02000
- Density:0.990±0.06 g/cm3(Predicted)
- LogP:6.87180
536721-25-2 Relevant articles
AN IMPROVED PROCESS FOR PREPARATION OF LIRAGLUTIDE
-
Page/Page column 11-12, (2021/07/02)
The present invention relates to an impr...
A Nickel(II)-Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides
Pedersen, Simon S.,Donslund, Aske S.,Mikkelsen, Jesper H.,Bakholm, Oskar S.,Papp, Florian,Jensen, Kim B.,Gustafsson, Magnus B. F.,Skrydstrup, Troels
, p. 7114 - 7123 (2021/03/03)
A series of pharmaceutically relevant sm...
IMPROVED PROCESSES FOR THE PREPARATION OF PEPTIDE INTERMEDIATES/MODIFIERS
-
Page/Page column 15-16, (2020/10/21)
The present application relates to impro...
Preparation method of high-purity liraglutide side chain
-
Paragraph 0048-0049, (2019/07/04)
The invention discloses a preparation me...
536721-25-2 Process route
-
-
14464-31-4
palmitic acid N-succinimide ester
-
-
45120-30-7
L-glutamic acid α-tert-butyl ester
-
-
536721-25-2
L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester
| Conditions | Yield |
|---|---|
|
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 - 30 ℃;
for 3.5h;
|
93% |
|
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
for 2h;
|
74% |
|
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 64h;
|
|
|
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
for 2h;
|
1.2 g |
|
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 48h;
|
5 g |
|
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
at 20 ℃;
|
|
|
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
at 20 ℃;
|
|
|
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
|
-
-
45120-30-7
L-glutamic acid α-tert-butyl ester
-
-
112-67-4
n-hexadecanoyl chloride
-
-
536721-25-2
L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester
| Conditions | Yield |
|---|---|
|
at 20 ℃;
for 3.5h;
Phosphate buffer;
|
|
|
With
sodium carbonate;
In
tetrahydrofuran; water;
at 3 ℃;
for 3h;
|
536721-25-2 Upstream products
-
14464-31-4
palmitic acid N-succinimide ester
-
45120-30-7
L-glutamic acid α-tert-butyl ester
-
112-67-4
n-hexadecanoyl chloride
-
105590-97-4
L-glutamic acid γ-benzyl α-tert-butyl ester hydrochloride
536721-25-2 Downstream products
-
204521-63-1
Nα-hexadecanoyl-L-glutamic acid α-tert-butyl ester γ-succinimidyl ester
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-
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