204521-63-1

  • Product Name:Pal-Glu(Osu)-OtBu
  • Molecular Formula:C29H50N2O7
  • Purity:99%
  • Molecular Weight:538.725
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Product Details;

CasNo: 204521-63-1

Molecular Formula: C29H50N2O7

Buy high quality and low price Pal-Glu(Osu)-OtBu 204521-63-1 now

  • Molecular Formula:C29H50N2O7
  • Molecular Weight:538.725
  • Melting Point:86.0 to 90.0 °C 
  • PKA:14.40±0.46(Predicted) 
  • PSA:119.08000 
  • Density:1.08±0.1 g/cm3(Predicted) 
  • LogP:6.01040 

204521-63-1 Relevant articles

AN IMPROVED PROCESS FOR PREPARATION OF LIRAGLUTIDE

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Page/Page column 12, (2021/07/02)

The present invention relates to an impr...

IMPROVED PROCESSES FOR THE PREPARATION OF PEPTIDE INTERMEDIATES/MODIFIERS

-

Page/Page column 16, (2020/10/21)

The present application relates to impro...

Preparation method of high-purity liraglutide side chain

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Paragraph 0050-0065, (2019/07/04)

The invention discloses a preparation me...

Novel GLP-1 Analogues

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Paragraph 0117-0118, (2019/10/20)

The present disclosure pertains to novel...

204521-63-1 Process route

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester
536721-25-2

L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester

N<sup>α</sup>-hexadecanoyl-L-glutamic acid α-tert-butyl ester γ-succinimidyl ester
204521-63-1

Nα-hexadecanoyl-L-glutamic acid α-tert-butyl ester γ-succinimidyl ester

Conditions
Conditions Yield
With diisopropyl-carbodiimide; In dichloromethane; at 20 - 30 ℃; for 4h;
90%
With dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h;
With diisopropyl-carbodiimide; In dichloromethane; acetonitrile; for 48h;
With 4-methyl-morpholine; isobutyl chloroformate;
With diisopropyl-carbodiimide; In tetrahydrofuran; at 40 - 50 ℃;
With dicyclohexyl-carbodiimide; In ethyl acetate; at 20 ℃; for 12h;
L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester
536721-25-2

L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester

O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
105832-38-0

O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

N<sup>α</sup>-hexadecanoyl-L-glutamic acid α-tert-butyl ester γ-succinimidyl ester
204521-63-1

Nα-hexadecanoyl-L-glutamic acid α-tert-butyl ester γ-succinimidyl ester

Conditions
Conditions Yield
With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 2h;
With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 2h;

204521-63-1 Upstream products

  • 6066-82-6
    6066-82-6

    1-hydroxy-pyrrolidine-2,5-dione

  • 536721-25-2
    536721-25-2

    L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester

  • 57-10-3
    57-10-3

    1-hexadecylcarboxylic acid

  • 105832-38-0
    105832-38-0

    O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

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