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Fmoc-α-Me-Leu-OH | CAS 312624-65-0
- cas：312624-65-0
- Molecular Formula：C22H25 N O4
- Purity：99%
- Molecular Weight：367.445
Product Details;
CasNo： 312624-65-0
Molecular Formula： C22H25 N O4
Fmoc-α-Me-Leu-OH 312624-65-0 with purity >99% Low price in stock
- Molecular Formula:C22H25NO4
- Molecular Weight:367.445
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.578
- Boiling Point:562.652°C at 760 mmHg
- PKA:3.95±0.41(Predicted)
- Flash Point:294.082°C
- PSA：75.63000
- Density:1.19g/cm3
- LogP:4.80540
FMOC-ALPHA-ME-LEU-OH(Cas 312624-65-0) Usage
InChI:InChI=1/C22H25NO4/c1-14(2)12-22(3,20(24)25)23-21(26)27-13-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,14,19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t22-/m0/s1
312624-65-0 Relevant articles
Synthetic Modification within the rPRL Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation
McKinnie, Shaun M. K.,Wang, Wang,Fischer, Conrad,McDonald, Tyler,Kalin, Kevin R.,Iturrioz, Xavier,Llorens-Cortes, Catherine,Oudit, Gavin Y.,Vederas, John C.
, p. 6408 - 6427 (2017)
Apelin is an important mammalian peptide hormone with a range of physiological roles, especially in the cardiovascular system. The apelinergic system is a promising target for treatment of disease, but this remains to be realized due to rapid proteolysis of apelin-derived peptides by proteases, including neprilysin (NEP). The synthetic analogues modified within the NEP degradation site ( RPRL motif) showed improved in vitro proteolytic stability while maintaining receptor-binding affinities, with three candidate peptides retaining full cardiovascular activities for potential therapeutic application. Many such analogues proved physiologically inactive even with relatively conservative modifications, highlighting the importance of this region for full agonist activity of this peptide hormone.
Synthetic method of (2S)-2-N-fluorene methoxycarbonyl amino-2,4-dimethyl valerate
-
Paragraph 0010; 0011; 0012, (2019/03/08)
The invention relates to a synthetic method of (2S)-2-N-fluorene methoxycarbonyl amino-2,4-dimethyl valerate. According to the synthetic method, the technical problems that potassium cyanide is highlytoxic, and the enzymatic resolution yield is low in an
312624-65-0 Process route
-
- 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
-
- 105743-53-1
(S)-2-amino-2,4-dimethylpentanoic acid
-
- 312624-65-0
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2,4-dimethylpentanoic acid
| Conditions | Yield |
|---|---|
|
With sodium hydroxide; In water; acetone; at 30 ℃; for 12h; pH=9.5; pH-value; Large scale;
|
60% |
-
-
C32H35N3NiO3
-
- 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
-
- 312624-65-0
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2,4-dimethylpentanoic acid
| Conditions | Yield |
|---|---|
|
C32H35N3NiO3; With hydrogenchloride; In methanol; at 70 ℃; for 0.75h;
With sodium carbonate; In water; at 20 ℃; for 0.5h;
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In water; acetone; at 0 - 20 ℃; for 22h;
|
95% |
312624-65-0 Upstream products
-
82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
-
105743-53-1
(S)-2-amino-2,4-dimethylpentanoic acid
-
865468-88-8
C22H23NO4
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