Reduced Glutathione | CAS 70-18-8

Product Details

CasNo： 70-18-8

Molecular Formula： C10H17N3O6S

Appearance： White to almost white powder

Delivery Time： Confirmed according to order quantity, target specification, packaging requirements, and current supply availability

Packing： Available according to order quantity and project requirements

Throughput： Evaluated based on project requirements, specifications, and order quantity

Purity： ≥98%

Product Overview

Reduced Glutathione, CAS 70-18-8, also known as L-Glutathione Reduced or GSH, is a naturally occurring tripeptide composed of glutamic acid, cysteine, and glycine.

Its structure is commonly represented as γ-Glu-Cys-Gly, in which glutamic acid is linked to cysteine through a γ-glutamyl bond. Reduced Glutathione has the molecular formula C10H17N3O6S and a molecular weight of approximately 307.33 g/mol.

In cosmetic and personal-care formulations, Reduced Glutathione is used as a functional cosmetic ingredient in antioxidant-focused and skin-conditioning formulations. It can be evaluated for use in serums, creams, lotions, and multi-active skin-care systems.

Shandong Juntai Pharmaceutical supports B2B supply of Reduced Glutathione for cosmetic brands, formulation laboratories, ingredient distributors, and personal-care R&D projects. Assay, packaging, analytical specifications, and supporting documentation are confirmed according to the actual batch and project requirements.

Product Information

Item	Information
Product Name	Reduced Glutathione
INCI Name	Glutathione
Synonyms	L-Glutathione Reduced / GSH / Reduced L-Glutathione
CAS No.	70-18-8
EC No.	200-725-4
Molecular Formula	C10H17N3O6S
Molecular Weight	307.33 g/mol
Peptide Type	Tripeptide
Structural Representation	γ-Glu-Cys-Gly
Components	Glutamic Acid / Cysteine / Glycine
Product Category	Cosmetic Active Ingredient
Appearance	White to almost white powder
Typical Assay	≥98%
Main Applications	Serums, creams, lotions, and multi-active cosmetic formulations
Storage	Keep sealed, protected from light and moisture, preferably under cool conditions

Product Features

Defined Reduced Glutathione Structure

Reduced Glutathione is a tripeptide composed of glutamic acid, cysteine, and glycine.

Unlike a conventional linear tripeptide, the glutamic acid residue is connected to cysteine through its γ-carboxyl group, giving the molecule its characteristic γ-Glu-Cys-Gly structure.

The cysteine residue contains a free thiol group, which is an important structural feature of the reduced form.

Reduced Glutathione Is Different from Oxidized Glutathione

Reduced Glutathione and Oxidized Glutathione should not be treated as interchangeable raw materials.

Item	Reduced Glutathione	Oxidized Glutathione
Common Abbreviation	GSH	GSSG
Product Form	Reduced form	Oxidized form
CAS No.	70-18-8	Different CAS record
Product on This Page	Yes	No

For B2B sourcing, specifying Reduced Glutathione / GSH helps avoid confusion between the two forms.

Suitable for Cosmetic Formulation Development

For cosmetic ingredient qualification, Reduced Glutathione should be evaluated using more than a single assay value.

Relevant parameters may include:

• Assay / purity
• Identity
• Appearance
• Solubility
• Loss on drying
• Related substances
• Oxidized glutathione level
• Heavy metals
• Microbial limits
• Storage stability

These factors provide a more useful basis for cosmetic formulation development and raw-material qualification.

Formulation Stability Requires Attention

Because Reduced Glutathione contains a reactive thiol group, its stability can be influenced by formulation and storage conditions.

Formulators should consider:

• Oxygen exposure
• Light
• Temperature
• pH
• Metal ions
• Other active ingredients
• Packaging conditions

Final compatibility and stability should be confirmed in the complete formulation rather than inferred from the raw material alone.

Applications

Facial Serums

Reduced Glutathione can be evaluated for use in facial serums and concentrated multi-active formulations as a functional cosmetic ingredient.

Its compatibility with other actives should be verified through formulation-specific stability testing.

Creams and Lotions

GSH may also be incorporated into creams, lotions, emulsions, and other leave-on skin-care products.

Processing conditions, pH, exposure to air, and interactions with other ingredients should be reviewed during formulation development.

Antioxidant-Focused Cosmetic Formulations

Reduced Glutathione is commonly associated with redox and antioxidant systems and can be used in formulations designed around antioxidant ingredient positioning.

For cosmetic communication, appropriate wording includes:

• Antioxidant cosmetic ingredient
• Skin-conditioning formulation
• Functional cosmetic active
• Multi-active skin-care formulation

This keeps product positioning within a cosmetic context rather than presenting it as a therapeutic ingredient.

Multi-Active Skin-Care Systems

Reduced Glutathione may be combined with other cosmetic ingredients in multi-active formulations.

Where peptides, vitamin derivatives, botanical actives, or other antioxidant ingredients are used together, compatibility and long-term stability should be evaluated in the final formula.

Quality & Supply

Reduced Glutathione quality should be evaluated through a combination of assay, identity, impurity control, and formulation-related parameters.

Quality Item	Typical Requirement / Consideration
Assay / Purity	Common target ≥98%
Identity	Confirmed according to analytical specification
Molecular Formula	C10H17N3O6S
Molecular Weight	307.33 g/mol
Appearance	White to almost white powder
Related Substances	Confirmed according to batch specification
Oxidized Glutathione	Confirmed where required
Loss on Drying	Confirmed according to batch specification
Heavy Metals	Confirmed according to applicable specification
Microbial Limits	Confirmed where required
Solubility	Evaluated according to product and formulation conditions
Storage	Sealed, protected from light and moisture, preferably under cool conditions

A ≥98% assay is commonly seen in commercial Reduced Glutathione materials, but final specifications should always be based on the actual supply batch.

Shandong Juntai Pharmaceutical can review supply requirements according to target quantity, assay, packaging format, and formulation needs.

If a project requires specific assay, HPLC data, related-substance limits, oxidized glutathione level, heavy metals, microbial limits, solubility information, or technical documentation, these requirements can be submitted during the inquiry stage for confirmation.

Custom Support

Projects involving Reduced Glutathione and other functional cosmetic ingredients can be discussed according to formulation and sourcing requirements.

Project support may include:

• Reduced Glutathione raw material supply
• Target assay requirements
• Cosmetic formulation projects
• Packaging specification review
• Analytical requirement review
• Quality specification communication
• Formulation-related technical discussion
• Related antioxidant or peptide cosmetic ingredients

Specific supply conditions are evaluated according to order quantity, target specification, quality requirements, and current production conditions.

Frequently Asked Questions

Is Reduced Glutathione the same as Glutathione?

In raw-material sourcing, Reduced Glutathione, L-Glutathione Reduced, and GSH commonly refer to the reduced form associated with CAS 70-18-8.

For procurement purposes, specifying “Reduced” is recommended to avoid confusion with Oxidized Glutathione, or GSSG.

Is Glutathione a peptide?

Yes. Glutathione is a tripeptide composed of glutamic acid, cysteine, and glycine.

Its structure is commonly represented as γ-Glu-Cys-Gly.

What assay is commonly requested for Reduced Glutathione?

A common commercial target is ≥98%.

Actual assay, analytical method, and impurity limits should be confirmed against the specific supply batch and COA.

What cosmetic products can use Reduced Glutathione?

Reduced Glutathione can be evaluated for use in serums, creams, lotions, and other multi-active cosmetic formulations.

Final use conditions should be determined according to formulation compatibility, stability testing, and applicable cosmetic regulations.

What should formulators consider when using Reduced Glutathione?

Key considerations include pH, oxygen exposure, temperature, light, metal ions, compatibility with other active ingredients, and packaging conditions.

Finished-product stability should be verified through formulation-specific testing.

What quality parameters should buyers check?

In addition to assay, buyers may consider:

• Identity
• Related substances
• Oxidized glutathione level
• Loss on drying
• Heavy metals
• Microbial limits
• Appearance
• Solubility
• Storage requirements

The exact specification should match the intended formulation and target market.

Can COA and technical documentation be provided?

Availability of COA, analytical data, and other technical documentation depends on the actual supply batch.

Specific testing or documentation requirements can be provided during the inquiry stage for confirmation.

What is the MOQ for Reduced Glutathione?

MOQ depends on the requested specification, order quantity, packaging format, and current supply conditions.

Providing the expected purchase quantity helps determine an appropriate supply option.

What is the typical lead time?

Lead time depends on order quantity, target assay, packaging requirements, and current supply availability.

Projects requiring special specifications or additional testing may require a project-specific lead-time evaluation.

For use as a cosmetic ingredient. Final formulations should comply with applicable cosmetic regulations and product-safety requirements in the target market.