AEEA-AEEA (CAS 1143516-05-5): PEG-Based Linker Intermediate for ADC and PROTAC Research
2026.08.11
AEEA-AEEA (CAS 1143516-05-5): PEG-Based Linker Intermediate for ADC and PROTAC Research
Meta Description:
AEEA-AEEA (CAS 1143516-05-5) is a PEG-based linker intermediate used in ADC and PROTAC research. Shandong Juntai Pharmaceutical provides high-purity material with analytical documentation and customized synthesis support.
Introduction
Linker chemistry plays an important role in the design of advanced molecular platforms, including antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). The selection of linker structures can influence molecular architecture, conjugation properties and the overall characteristics of designed molecules.
AEEA-AEEA (CAS No. 1143516-05-5) is a PEG-based amino acid derivative containing amino and carboxylic acid functional groups. Its bifunctional structure provides a flexible chemical framework for linker-related research, including ADC linker development, PROTAC linker design and other molecular modification studies.
Shandong Juntai Pharmaceutical supplies high-purity AEEA-AEEA with analytical documentation and customized synthesis support for global research and development customers.
AEEA-AEEA Chemical Information
| Item | Specification |
|---|---|
| Product Name | AEEA-AEEA |
| CAS No. | 1143516-05-5 |
| Molecular Formula | C₁₂H₂₄N₂O₇ |
| Molecular Weight | 308.33 g/mol |
| Appearance | White to off-white solid |
| Purity | ≥99% (HPLC) |
| Storage | 2-8°C, protect from light |
ADC Linker Considerations
In ADC development, linker systems are designed to connect targeting molecules with functional payload components. The selection of linker structures requires consideration of molecular distance, chemical compatibility and conjugation performance.
PEG-based linker structures are widely investigated in ADC research due to their hydrophilic characteristics and flexible molecular architecture. These properties allow researchers to evaluate different linker designs for optimizing conjugation strategies and molecular characteristics.
AEEA-AEEA can be explored as a PEG-based linker intermediate in ADC-related chemical research, particularly in applications requiring flexible spacer structures and functional group compatibility.
PROTAC Linker Selection: Role in Ternary Complex Formation
PROTAC molecules consist of three key components: a target protein ligand, an E3 ligase ligand, and a linker connecting both functional units. The linker directly influences the formation of the ternary complex—the simultaneous binding of the PROTAC to both the target protein and E3 ligase—which is essential for ubiquitination and subsequent proteasomal degradation.
Key Linker Parameters in PROTAC Design
| Parameter | Impact on PROTAC Function |
|---|---|
| Linker length | Determines optimal distance for ternary complex formation |
| Linker flexibility | Affects conformational adaptability and binding cooperativity |
| Hydrophilicity/hydrophobicity | Influences cellular permeability and overall solubility |
| Chemical stability | Impacts metabolic stability and pharmacokinetic properties |
PEG-Based Linkers in PROTAC Development
PEG-based structures are frequently evaluated in PROTAC linker research for several reasons:
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Flexible molecular connections enable optimal orientation of the two ligands for productive ternary complex formation
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PEG segments can improve the overall hydrophilicity of PROTAC molecules, which often contain hydrophobic regions
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The length and composition of PEG linkers can be adjusted to achieve desired molecular properties
AEEA-AEEA can be investigated as a PEG-based linker component in PROTAC-related molecular design, particularly where a hydrophilic spacer is needed to bridge two functional domains while maintaining conformational flexibility.
Functional Groups and Synthetic Flexibility
The amino and carboxylic acid groups within AEEA-AEEA provide opportunities for further chemical modification during linker synthesis and molecular optimization. These functional groups enable researchers to introduce structural variations according to different design requirements, supporting the development of customized linker structures and related chemical applications.
Quality and Supply Support
Shandong Juntai Pharmaceutical provides:
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High-purity AEEA-AEEA (≥99% by HPLC)
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Complete COA documentation with HPLC and MS analytical data
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Flexible packaging options from grams to bulk quantities
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Customized synthesis and scale-up services
With expertise in pharmaceutical intermediates, peptide-related building blocks and custom synthesis, the company supports global customers with reliable chemical supply solutions.
Related Products and Services
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PEG-based linker intermediates
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Peptide synthesis building blocks
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Custom synthesis services for complex intermediates
